Ø Cleansing cream (Harry’s p 58)
| Formula standart | Formula modifikasi |
| Mineral oil 18% | Mineral oil 18% |
| Glyseril stearate 15% | Cetyl alcohol 2% |
| Cetyl alcohol 2% | Glyseril stearate 15% |
| Spermaceti 5% | Metyl paraben 0,1% |
| Parfume q.s | Spermaceti 5% |
| Water q.s | Parfume q.s |
|
| Water q.s |
Alasan : sediaan yang didapatkan memiliki bentuk yang bagus dan secara keseluruhan juga bagus, akan tetapi pH sediaan memiliki perbandingan pH yang agak berbeda dengan pembanding, dimana hal ini mungkin karena tidak menggunakan alkalizing agent dalam pembuatan
Ø Sunscreen gel
| Formula standart ( cosmetics & toilotery, ed 2nd, p 815) | Formula modif |
| Water 10,8% | Water |
| Carbopol 940 55% | Carbomer 1,1 % |
| Sd-alcohol 39C 5% | Etanol 5,0% |
| Germaben II | TEA 5,5% |
| PG 5% | Nipagin 0,1% |
| Cremogen aloe vera 2% | Nipasol 0,1% |
| TEA 99% 2,2% | IPM 2,0% |
| DL-Panthenol 0,5% | PG 5% |
| Neo heliopan hydro 6,7% | Aloe vera 2% |
| 30% TEA salt | ZnO 5% |
| Sandoxylate SX 0,3% | Oxybenzone 1% |
|
| BHT 1% |
Alasan : form. Standart hny menggunakan 1 sunscren agent UV yg bkrj scr fisika (ZnO). Oxybenzone memilki range panjang gelombang yg luas sehingga dpt mengabsorbsi UVA dan UVB. Kombinasi ZnO + Oxybenzone dpt meningkatkan kerja dari sunscreen karena oxybenzone akan mengabsorbsi sinar UV dan ZnO akan memantulkan sinar UV ( wikipedia, sunscreen)
Ø Whitening lotion & lightening lotion
| Formula standart (Harry’s cosmectiology, p.268) | Formula Modif |
| Lexemus As 5% | Laxemul As 5% ( glyceril stearat 5% & na lauryl sulfat 0,9%) |
| Mineral oil light NF 2,5% | Mineral oil 2,5% |
| IPM 2.5% | IPM 2,5% |
| Cetyl alcohol 1% | Cetyl alcohol 1% |
| Brij 35 0,9% | Gliserin 10% |
| Air 99,95% | Na lauryl sulfat 2% |
| PG 5% | Na metabisulfit 0,2% |
| Na Lauryl sulfat 0,9% | As.askorbat 0,1% |
| Na metabisulfit 0,15% | Arbutin 3% |
| As. Askorbat 0,1% | Tween 80 4% |
| Hidroquinone 2% | Air 72,2% |
| As. Sitrat 0,1% | Ada yg d + brij 35 |
Alasan : Hidroquinone memiliki efek samping lebih besar dibanding arbutin, hidroquinone dpt mnghmbt sintesis RNA dan DNA, sehingga resiko mutagenesis meningkat ( cosmetic and formulation of skin care products, 2006)
Ø Hand and body lotion
| F. standart (cosmetic & toiletry 2nd vol 6 p.218) | Formula modif |
| Carbopol 934 0,15% | Carbomer 0,17% |
| Metyl paraben 0,2% | Metyl paraben 0,15% |
| Propyl paraben 0,1% | Propyl paraben 0,17% |
| Carnation mineral oil 4% | Mineral oil 3,43% |
| PG 0,8% | PG 0,69% |
| Disodium edetate 0,1% | Disodium edetate 0,09% |
| Glycerin 5% | Glycerin 4,29% |
| Lanolin alcohol 0,5% | Lanolin alcohol 0,42% |
| Stearic acid 2% | Stearic acid 1,71% |
| Glyceril stearate 0,5% | Glyceril stearate 0,43% |
| Dimethicone 0,5% | Silicon oil 8,57% |
| Cetyl alcohol 0,2% | Squalene 2,57% |
| Triethanolamine 1% | Triethanolamine 0,86% |
| Deionized water 84,95% | Aqua 76,45% |
| Fragnance q.s | Fragnance q.s |
Alasan : cetyl alcohol diganti squalene krn msng2 memiliki fungsi yang sama, selain itu squalene dapat meningkatkan permeabilitas kulit, sehingga lotion dapat bkrj lbh cpt.
Ø Hand sanitizer Gel
| F.standart ( Harry’s cosmeticology p.89) | F. modif |
| Deodorized keposene 35% | Trictoson 0,5% |
| Lanoline 10% | Lanoline 10% |
| Cocaxide DEA 4% | Cocaxide DEA 4% |
| Stearic acid 2,43% | Stearic acid 4,5% |
| Oleic acid 3,64% | Oleic acid 3,64% |
| Sod. Hydroxide 0,38% | NAOH 0,38% |
| Water 44,55% | Mineral oil 32,93% |
| Perfume, color, preservative q.s | Nipagin 0,2% |
|
| Nipasol 0,1% |
|
| Water 43,75% |
|
| PG 0,8% |
Alasan: bahan aktif menggunakan trictosan, krn trictosan aktif sebagai baktriostatik untuk mikroba gram + & -. Selain itu juga efektif untuk mengontrol & mereduksi bakteri pd tangan.
Penigkatan kons. Stearic acid agar sediaan tidak pecah.
Ø Sunscreen cream
| F.standart (harry’s cosmeticology p.254) | F.modif |
| Sunscreen, etc q.s | Oxybenzone 6% |
| Cetyl alcohol 1% | Octyl methoxycinnamate 7,5% |
| Glycerin 7% | Cetyl alcohol 2% |
| Sesame oil 10% | Glycerin 6,5% |
| Glyseril monostearat 16% | Sesame oil 10% |
| Mineral oil 10% | Glyceril monostearate 16% |
| Preservative q.s | Nipagin 0,18% |
| Antioxidant q.s | Nipasol 0,02% |
| Water to 100% | PG 0,7% |
| Parfume q.s | TEA |
Alasan : Modif pd sunscreen diberi oxybenzone dikombinasikan dengan octyl methoxycinnamate agar bkrj lbh efektif.
Ø Topical sunscreen cream o/w
| F. standart (harry’s cosmeticology p.253) | F.modif |
| Giv-tan-f 1,5% | Oksibenzone 3% |
| Diethylene glycol monostearat 2% |
|
| Asam asetat 3,5% | Asam stearat 3,5% |
| Cetyl alkohol 0,4% | Cetyl alcohol 2% |
| Isopropyl miristat 4% |
|
| TEA 1% | TEA 1% |
| TEA-lauryl sulfat 0,75% | TEA-lauryl sulfat 0,75% |
| Water 86,85% | Nipagin 0,18% + nipasol 0,02% |
|
| PG 2% |
|
| Water 80,55% |
Alasan : gliv-tan-f hanya sebagai UV-B, sdgkn oxybenzone sebagai penyerab UV-A & UV-B
Ø Cleanising lotion o/w
| F.standart (cosmetics & toeletry form,ed 2n,p.266) | F.modif |
| Mineral oil 15% | Mineral oil 15% |
| Beeswax 0,5% | Beeswax 0,5% |
| Ceresin was 0,5% | Ceresin was 0,5% |
| Sorbo 27% | Sorbitol 27% |
| Arlacel 186(glycerol monostearat + PG) 3% | Glyseril monostearat 3% |
| Tween 80 0,5% | Tween 60 0,5% |
| Water 53,50% | Nipagin 0,18% |
| Preservative q.s | Nipasol 0,02% |
|
| PG 2% |
|
| Water 48,73% |
|
| Bhn aktif= lime extract |
|
|
|
Ø Night cream o/w
| F.standart (cosmetic &toeletry form ed2nd,vol1,p.227) | F.modif |
| Cetyl alcohol 2% | Idem |
| Glyceril monostearat 5% | Idem |
| Triethanolamine 1% | Idem |
| Mineral oil 10% | Idem |
| PG 4% | Idem |
| Amerchol BL 8% | Idem |
| Amerlate P(lanolate) 2% | Idem |
| Sperm wax 4% | Idem |
| Silicon fluid 200 1% | Silicon oil 1% |
| Parfume and preservative q.s | Nipagin 0,18% |
| Water 58% | Nipasol 0,02% |
|
| Ascorbic acid 0,1% |
|
| Ekstrak bengkoang 5% |
|
| Water 57,7% |
Alasan : -. Sediaan akhir modif msh agak keras, shg hrs di + kons air dan me- fs mnyk.
-. Yg dkrngi cetyl alcohol yg d rbh, airnya tetap
-. Untuk Ph yg turun di + NaOH
Ø Sunscreen lotion w/o ( harry’s cosmeticologi p.254)
| F.standart | F. modif |
| Sunscreen 3% | UV-B 5% |
| Glyseril monostearate 16% | Glyceril monostearate 2,5% |
| Cetyl alcohol 1% | Cetyl alcohol 1% |
| Mineral oil 10% | Mineral oil 20% |
| Sesame oil 10% | Sesame oil 10% |
| Glycerin 7% | Glycerin 29% |
| Water | Water 31,7% |
| Antioxidant q.s | BHT 0,1% |
| Preservative (pengawet) | Nipagin 0,18% |
|
| Nipasol 0,02% |
| Parfum | Carbomer 0,3% |
|
| TEA q.s |
|
|
|
Alasan :-. kons glyceril monostearat di trnkn dan % glycerin ditingkatkan dan mineral oil ditingkatkan
-. Pecah dikrnkan kurang pengadukan yng baik , bkn kurang carbomer.
-. Tp kalo ngaduk masih pecah beartikurang emulsifying agent
-. 0,3% berarti bkn carbomer.
Ø Nail cream o/w ( cosmetic & toiletry formulation 2nd vol 1)
| F.standart | F. modif |
| Beeswax (white) 1% | Idem |
| Lanolin 10% | Idem |
| Asam stearat 1,5% | Idem |
| Mineral oil 20% | Idem |
| S-MAZ 60 ( SPAN 60) 2% | Idem |
| Propyl paraben 0,1% | Idem |
| Borak USP 0,2% |
|
| Glycerine CP/USP 5% | Idem |
| Trierhanolamine 0,7% | Idem |
| Deionized water polisorbat 58,1% | Idem |
| T-MAZ 60 (Tween 60) 1% | Idem |
| Metyl paraben 0,2% | Idem |
|
| Vitamin E 0,5% (range 0,1-1%) |
| Cetyl alcohol 0,2% | Idem |
Alasan : pH terlalu basa, sediaan terlalu cair, krg kreatif, tdk ada modif base
Ø Sunscreen gel ( Harry’s cosmeticology p.252)
| F. standart | F.modif |
| Sunscreen ( water soluble) 5% | Zink oxida 5% |
|
| Oxybenzone 3% |
| Carbopol 934 0-1% | Carbomer 1% |
| Sodium hydroxide 10% 0,42% | TEA 0,25% |
|
| Metil paraben 0,2% |
|
| Etanol 13% |
| Water 80% | Water |
|
| Isopropyl myristat 4% |
|
| Gltcerin 20% |
| 1,2,6 hexanetriol 15% |
|
Alasan : sebenarnya tdk perlu ditambah ZnO soalnya ZnO sifatnya hidrofob kalo cara nyampur g benar hasilnya g benar alias g jadi. ( ZnO / tIo2 hrs diayak dulu)
Ø Massage cream (harry’s p.71)
| F. standart | F. modif |
| Stearic acid 15% | Cetyl alcohol 3% |
| Lanolin 2% | Idem |
| Beeswax 2% | Idem |
| Mineral oil 24% | Idem |
| PEG-40 stearat 5% | Petrolatum jelly 18% |
| Sorbitol 10% |
|
| Wate q.s | Water q.s |
| Perfume q.s | Perfume q.s |
| Preservative q.s | Na benzoat 0,3% |
Alasan : PEG diganti petrolatum jelly, asam stearat diganti cetyl alcohol. Vaselin menyebabkan lunak. Na benzoat bersifat asam. Mineral oil mdh teraksidasi/ perubahan shg di + BHT harusnya untuk menstabilkan Ph
Ø Nail massage cream ( toiletri vol 5 p.201)
| F.standart | F. modif |
| Dehymus E (10% w/w) |
|
| Dicocoyl pentaesy-thrityl distearyl atrak | Lanolin 5% |
| Aluminium stearates |
| Sorbitan sesquioleate | Glycerin 2,5% |
| Cera alba | Cera alba 2,5% |
| Cutina BW (3% w/w) |
|
| Glyceril hidroxy stearate | Glyceril monostearate 2,5% |
| Cetyl parmite | Cetyl alcohol 4% |
| Microcrystalline wax | Parrafin wax 2,5% |
| Trihydroxyiysstearin |
|
| Vaselin white (15% w/w) | Vaselin white 15% |
| Oil of st john wort CIR (3% w/w) |
|
| Olea europea | Olive oil 3% |
| Hypericum perforatum | Tocopherol 4% |
| Tocopherol |
| Avocado oil (5% w/w) |
| Carrot oil (2% w/w) |
| Cotiol v (12% w/w) |
| De cyl oleate |
| Water (50) | Water 55.8% |
|
| Metyl paraben 0,18% |
|
| Propyl paraben 0,02% |
|
| Propilen gliko 3% |
Ø Whitening cream w/o ( harry’s p.268)
| F.standart | F.modif |
| Lexemus As 1 5% | Lexemus As 1 1,37% |
| Glyseril stearat |
|
| Na Lauryl sulfat |
|
| Lexale TA 6% |
|
| Glyseril stearat | Glyseril stearat 0,45% |
| Isopropyl myristat | Isopropyl myristat 5,5% |
| Stearil stearat |
|
| Stearil alcohol 3% | Idem |
| Silicon oil 1% | Silicon oil 22% |
| Propilen glikol 5% | Propilen glikol 8% |
| Sodium metbisulfat 0,05% | Idem |
| Ascorbic acid 0,05% |
|
| Hidroquinon 2% | Arbutin 1% |
| Propil paraben 0,1% | Propil paraben 0,02% |
| Water 67,8% | Water 48,45% |
|
| Metil paraben 0,16% |
Alasan : -. silikon oil ditingkatkan
-. Propylen gliokol ditingkatkan
-. Asam askorbat tdk dipake karena digunakan sbgi lightening
-. Basis blm ada yg diganti, mk krng
-. Untuk penggunaan ascorbic acid dan arbutin hrs hati2 konsnya. Itu akan mempengaruhi sediaannya.
